FADD mouse mAb
簡要描述:FADD mouse mAb宿主: Monoclonal, Mouse反應性: Human應用: WB
產品型號: YP-Ab-00109
所屬分類:單克隆抗體
更新時間:2024-11-01
詳細說明:
FADD mouse mAb
抗體,也叫免疫球蛋白(Ig),是一種能特異性結合抗原的糖蛋白,而抗原是在易感染動物體內引發抗體產生的物質。在體內,抗體是由于外源性分子的侵襲而產生的??贵w以一個或者多個Y字形單體存在,每個Y字形單體由4條多肽鏈組成,包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據它們的分子量大小來命名的。Y字形結構的頂端是可變區,為抗原結合部位。任何一個抗體的輕鏈都可以分為κ或λ型(基于小分子多肽結構上的差異),每一個抗體的重鏈則決定了它的類或型。
產品詳情
This antibody detects endogenous levels of FADD and does not cross-react with related proteins.
免疫原詳細信息
Purified recombinant human FADD protein fragments expressed in E.coli.
相關試劑
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008],
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備注:圖片僅供參考。僅供科研,不可用于臨床。