Bag-3 Polyclonal Antibody detects endogenous levels of Bag-3 protein.

The antiserum was produced against synthesized peptide derived from the Internal region of human BAG3. AA range:311-360

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008].